British Air Force Typhoon FGR4s have conducted a mission with French aircraft in a combined operation on an subterranean weapons facility in Syrian territory used by the IS group, as stated by the UK Ministry of Defence.
The site, located using intelligence, was thought to be storing arms and explosives, the statement said, and was located in mountainous terrain just north of the ancient city of Palmyra in Syria's central region.
"Our fighter planes utilized precision-guided Paveway IV munitions to strike a several approach shafts leading to the site... preliminary assessments suggest the objective was successfully hit," the ministry announced.
There was no indication of any civilian casualties in the operation conducted Saturday night and all the aircraft returned to base without incident, the MoD added.
The Typhoon FGR4s were supported by a Voyager refuelling tanker.
The Islamic State group - also known as ISIS - enforced militant control over parts of Iraq and Syria until 2019.
"This operation demonstrates our UK leadership, and resolve to work closely with our partners, to eliminate any revival of Daesh and their violent and radical beliefs in the Middle East," UK Defence Secretary John Healey said.
British military aircraft have conducted surveillance missions over Syrian airspace to "forestall any efforts to regroup" of IS subsequent to its defeat at the Baghuz confrontation in 2019, the authorities noted.
"I extend gratitude to all the members of our armed forces who took part in this operation for their professionalism and their courage," he said. "They were part of thousands of British personnel deployed over the holidays. This action, to remove dangerous terrorists who pose a risk to our way of life, shows how UK forces are always on standby, all year round, ensuring Britain's security domestically and strong abroad."
In December, the United States armed forces conducted what it termed a "major assault" targeting Islamic State objectives in Syria, following an ambush resulted in the deaths of two US troops and a local interpreter in Palmyra.
The United Nations estimates Islamic State still has an estimated 5,000 to 7,000 fighters in Iraq and Syria.